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How do tumor cells make their way from the tumor into the blood vessels? Three scenarios are depicted. In A, tumor blood vessels (red) expand so fast that the endothelial cell supply (pink) is unable to keep up. Gaps are created, exposing underlying tumor cells (black). In B, an endothelial cell is shed from the lining—possibly as a consequence of a tumor signal—exposing tumor cells beneath. In C, a tumor cell squeezes into the vessel, displacing an endothelial cell. Munn and Jain's findings are most consistent with B. Adapted from original by Lance Munn Back to Oncology